Effect of Betulinic Acid on Inducing Apoptosis of Human Multiple Myeloma Cell Line RPMI-8226 白桦脂酸对人多发性骨髓瘤细胞系RPMI-8226凋亡的诱导
Interaction of immobilized betulinic acid and phospholipase a2. 固定相白桦酸与磷脂质分解酵素交互作用的研究。
Nowaday a large quantity of betulinic acid derivatives with biological activity has been synthesized by structure modification. 对这类化合物的结构修饰和改造,目前已经获得大量具有良好生物活性的衍生物。
Design, Synthesis and Bioactivity Research of Steroidal Betulinic Acid Analogues with E Hetero-rings 具有E杂环的甾体结构的桦木酸结构类似物的设计、合成及生物活性研究
Preliminary Study on Betulinic Acid and Betulin Derivatives 'Anti-cancer Acitivity and Mechanism in Inducing Cell Apoptosis 桦木酸及桦木醇衍生物抗癌活性和诱导凋亡机理初步研究
This paper reviewed the study situation of several forest chemical products associated with medical and health ( products,) such as sterols, paclitaxel, betulinic acid and hinokitol. 综述了植物甾醇、紫杉醇、桦木酸、桧木醇等几种与医药保健品有关的林产化学品的研究开发现状。
Research progress and foreground of betulin and betulinic acid 白桦脂醇、白桦脂酸的研究进展及其前景
Selective oxidation of betulin for betulinic acid preparation 非金属选择性催化氧化桦木醇制备桦木酸
Betulin and betulinic acid are remarkable natural products. 白桦脂醇和白桦脂酸是非常有价值的天然产物。
? Objective To study 23 hydroxyl betulinic acid induced apoptosis and growth inhibition of B16 melanoma cell in vivo and in vitro. 目的研究23羟基桦木酸对体内、外B16黑色素瘤细胞生长的抑制及诱导凋亡作用。
Differentiation of B_ ( 16) melanoma cells induced by 23-hydroxyl betulinic acid 23-羟基桦木酸对B(16)细胞系的诱导分化作用
The influence of 23-hydroxyl betulinic acid on the proliferation and migration of blood vessel endothelial cell 23-羟基白桦酸对血管内皮细胞增殖和迁移的影响
M phase. Conclusions 23? hydroxyl betulinic acid significantly inhibited the proliferation of seven cancer cell lines by retarding cells at certain phase of cell cycle and finally caused cells apoptosis. 结论:23羟基桦木酸对体外7种恶性肿瘤细胞均有显著的抑制作用,并使细胞阻滞在某一生长期,最终导致肿瘤细胞凋亡。
Induction of apoptosis melanoma cell lines with betulinic acid and derivatives 桦木酸及其衍生物23-羟基桦木酸等诱导黑色素瘤细胞凋亡的研究
The anticancer effect of 23-hydroxyl betulinic acid in vitro 23-羟基桦木酸体外抗恶性肿瘤作用的研究
Synthesis and anti-tumor activity of 30-hydroxy derivatives of 23-hydroxy betulinic acid 23-羟基白桦脂酸的30位羟基衍生物的合成及其抗肿瘤活性
Studies on anti-tumor actions of betulinic acid in vivo 桦木酸体内抗肿瘤作用的初步研究
Objective To study the pharmacodynamics of betulinic acid on tumour cells of S_ ( 180) and H_ ( 22) and the Ca~ ( 2+), Mg~ ( 2+)-ATPase activity of tumor cell membrane of mice bearing tumor. 目的研究桦木酸对H22、S180小鼠肿瘤细胞药效学作用及对肿瘤细胞膜Ca2+、Mg2+-ATP酶活性的影响。
The study of 23-hydroxyl betulinic acid against melanoma in vivo and in vitro 23-羟基桦木酸体外和体内抗黑色素瘤作用的研究
The contain of betulin and betulinic acid are analyzed by GC. 利用GC色谱法测定了长白山白桦树皮中白桦脂醇和白桦脂酸的含量。
OBJECTIVE In the present study, the hepatoprotective activitis and molecular mechanism of Betulin and Betulinic acid ( BT& BA) were investigated on acute liver failure induced by D-galactosamine ( D-GalN)/ Lipopolysaccharides ( LPS) in vitro. 目的:探讨白桦酯醇和白桦酯酸对D-氨基半乳糖联合内毒素诱导急性肝衰竭动物模型的保护作用及其分子机制。
Several countries have already has extensive research into the chemical composition of birch bark, Birch in the result indicates that it is rich in Betulin and part of betulinic acid. 国外早已对白桦树皮化学组成进行了广泛的研究,结果显示它含有丰富的桦木醇和部分桦木酸等。
Betulin and betulinic acid are remarkable natural products. They are obtained from a variety of botanical sources. 白桦酯醇和白桦酯酸是非常有价值的天然产物,它们可以从丰富的植物资源中获得。
Betulinic acid and its derivatives were potential antitumor agents, which displayed a selective cytotoxicity on tumor cell lines but not on normal cells. 桦木酸及其衍生物具有选择性抑制肿瘤细胞生长的作用,是潜在的抗肿瘤药物。
Betulin relative advantages of betulinic acid modified with three points, looked after the modification activity strengthened. 桦木醇相对桦木酸的优势有三个修饰位点,进行修饰后望给予活性加强。
Annexin-V/ PI double staining flow cytometry revealed that apoptotic rate of RPMI-8226 cells increased as betulinic acid concentration increased. Annexin-V/PI双标流式细胞术示细胞凋亡率随药物浓度的增加而增加。
Betulinic acid is proved out a good promising medicine by this experiment. 实验证明白桦脂酸不失为一种很有前途的抗宫颈癌中药。
Betulin and Betulinic acid treatment could decrease serum AST, ALT activities and hepatic MDA level significantly, and critically increased hepatic GSH and CAT levels. 预防给予不同剂量的白桦酯醇或白桦酯酸可明显降低小鼠血清中ALT、AST和肝脏中MDA活性,提高GSH和CAT水平。